皮肤熏洗方联合火针治疗脾胃湿热型痤疮临床研究

Clinical Study on Skin Fumigation-Washing Prescription Combined with Fire Needle Therapy for Acne of Spleen-Stomach Damp-Heat Type

摘要:

目的：观察皮肤熏洗方联合火针治疗脾胃湿热型痤疮的临床疗效。方法：选取2025年1—11月平湖市中医院收治的60例脾胃湿热型痤疮患者为研究对象，按照随机数字表法分为对照组和观察组各30例。对照组给予火针治疗，观察组在对照组基础上联用皮肤熏洗方治疗，2组均治疗4周。比较2组临床疗效、皮损积分、中医证候评分、炎症水平、不良反应及复发情况。结果：观察组总有效率为100%（30/30），高于对照组80.00%（24/30）（P＜0.05）。治疗后，2组各项中医证候评分较治疗前降低（P＜0.05），且观察组各项中医证候评分低于对照组（P＜0.05）。治疗后，2组痤疮综合分级系统（GAGS） 评分较治疗前下降（P＜0.05），且观察组GAGS评分低于对照组（P＜0.05）。治疗后，2组白细胞介素（IL） -8、IL-6水平较治疗前下降（P＜0.05），且观察组IL-8、IL-6水平低于对照组（P＜0.05）。2组不良反应发生率比较，差异无统计学意义（P＞0.05）。治疗结束后3个月随访，观察组复发率低于对照组（P＜0.05）。结论：皮肤熏洗方联合火针治疗脾胃湿热型痤疮疗效显著，能改善皮损与中医证候，降低炎症因子水平，安全性高。

Abstract:

Abstract：Objective：To observe the clinical effect of skin fumigation-washing prescription combined with fire needle therapy in the treatment of acne of spleen-stomach damp-heat type. Methods：A total of 60 patients with acne of spleen-stomach damp-heat type admitted to Pinghu Hospital of Chinese Medicine from January to November 2025 were enrolled and divided into the control group and the observation group by the random number table method， with 30 cases in each group. The control group was treated with fire needle therapy alone，while the observation group received combined treatment with skin fumigation-washing prescription on the basis of the control group. Both groups were treated for four weeks. The clinical effects， skin lesion scores， traditional Chinese medicine （TCM） syndrome scores，inflammatory factor levels，and the adverse reactions and recurrence were compared between the two groups. Results：The total effective rate was 100% （30/30） in the observation group，higher than that of 80.00% （24/30） in the control group （P＜0.05）. After treatment， the TCM syndrome scores in both groups were decreased significantly （P＜0.05），and the observation group had lower scores than the control group （P＜0.05）. The scores of Global Acne Grading System （GAGS） in both groups were reduced after treatment （P＜0.05）， and the observation group showed lower GAGS scores （P＜0.05）. The levels of interleukin （IL）-8 and IL-6 in the two groups declined after treatment （P＜0.05）， with lower levels detected in the observation group （P＜0.05）. There was no significant difference in the incidence of adverse reactions between the two groups （P＞0.05）. The three-month follow-up after treatment revealed that the recurrence rate of the observation group was lower than that of the control group （P＜0.05）. Conclusion：The combination of skin fumigation-washing prescription and fire needle therapy has remarkable effects on acne of spleen-stomach damp-heat type. It can improve skin lesions and TCM syndromes， down-regulate inflammatory factor levels，and possesses high safety.