复方鱼腥草合剂联合阿莫西林克拉维酸钾治疗小儿急性上呼吸道感染外感风热证临床研究

Clinical Study on Compound Houttuyniae Herba Mixture Combined with Amoxicillin Clavulanate Potassium in Treating Pediatric Acute Upper Respiratory Tract Infection with External Contraction of Wind-Heat Syndrome

摘要:

目的：观察复方鱼腥草合剂联合阿莫西林克拉维酸钾治疗小儿急性上呼吸道感染外感风热证的临床疗效。方法：回顾性选取台州市中心医院/台州学院附属医院儿科2023年8月—2025年9月收治的急性上呼吸道感染外感风热证患儿98例，按照治疗方式不同分为对照组和联合组各49例。2组均持续治疗7天。比较2组临床疗效、急性上呼吸道感染症状、炎症指标［中性粒细胞百分含量（NEU%）、C-反应蛋白（CRP）、降钙素原（PCT）］ 和不良反应发生情况。结果：联合组临床疗效高于对照组，差异有统计学意义（P＜0.05）。治疗后，2组咳嗽、鼻塞、流涕、咽喉疼痛评分较治疗前降低（P＜0.05），且联合组咳嗽、鼻塞、咽喉疼痛评分低于对照组（P＜0.05）；2组治疗后流涕评分比较，差异无统计学意义（P＞0.05）。联合组发热、咽喉疼痛、咳嗽持续时间短于对照组（P＜0.05）。治疗后，2组NEU及CRP、PCT水平较治疗前降低，且联合组低于对照组，差异有统计学意义（P＜0.05）。2组不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：复方鱼腥草合剂联合阿莫西林克拉维酸钾可有效缓解小儿急性上呼吸道感染外感风热证症状，减轻炎症反应，提高临床疗效，治疗安全性较好。

Abstract:

Abstract： Objective： To observe the clinical effects of Compound Houttuyniae Herba Mixture combined with Amoxicillin Clavulanate Potassium in the treatment of pediatric acute upper respiratory tract infection with external contraction of wind-heat syndrome. Methods： A total of 98 children diagnosed with acute upper respiratory tract infection with external contraction of wind-heat syndrome，admitted to the Department of Pediatrics of Taizhou Central Hospital/Taizhou University Hospital from August 2023 to September 2025，were retrospectively enrolled and divided into the control group and the combination group according to the treatment regimens， with 49 cases in each group. Both groups received continuous treatment for seven days. The clinical effects， symptom scores of acute upper respiratory tract infection， inflammatory indicators [neutrophil percentage （NEU）， C-reactive protein （CRP）， procalcitonin （PCT）]， and incidence of adverse reactions were compared between the two groups. Results： The combination group achieved superior clinical effects compared to the control group （P＜0.05）. After treatment， the scores of cough，nasal congestion，rhinorrhea，and sore throat in both groups were decreased （P＜0.05）；the scores of cough，nasal congestion，and sore throat in the combination group were lower than those in the control group （P＜ 0.05）. There was no significant difference being found in rhinorrhea score between the two groups （P＞0.05）. The duration of fever， sore throat， and cough duration in the combination group was shorter than that in the control group （P＜0.05）. After treatment，NEU，CRP，and PCT levels in both groups declined，and the combination group showed lower levels than the control group， the difference being significant （P＜0.05）. There was no significant difference in the incidence of adverse reactions between the two groups （P＞0.05）. Conclusion： Compound Houttuyniae Herba Mixture combined with Amoxicillin Clavulanate Potassium can effectively relieve symptoms， alleviate inflammatory responses，and improve clinical effects in children with acute upper respiratory tract infection of external contraction of wind-heat syndrome，with favorable safety.