基于数据挖掘分析雄激素性脱发中医证型与用药规律的南北差异

Analysis of Regional Differences Between Northern and Southern China in Traditional Chinese Medicine Syndrome Types and Medication Patterns for Androgenetic Alopecia Based on Data Mining

摘要:

目的：基于数据挖掘分析雄激素性脱发（AGA） 中医证型与用药规律的南北差异。方法：检索中国知网、万方、维普及中国生物医学文献数据库中AGA的相关文献，依据纳排标准筛选AGA相关的临床研究，提取中医证型、病例数、处方用药及地区等信息，进行药物频次、性味归经、中医证型统计，并对高频用药进行关联规则及聚类分析。结果：共纳入136篇文献，涉及病例14 842例、内服处方98首、中药153味。AGA核心证型以湿热证、肝肾亏虚证为主，南方血虚证较多，北方血热证高发。高频药物为甘草、茯苓、泽泻等；药性多寒、温、平，药味多甘、苦、辛，归经主要归肝、脾、肾经。聚类分析得到3组核心组合；关联规则显示北方核心药对包括白术→川芎、白术→猪苓等，南方则为茯苓→泽泻、丹参→山楂等。结论：AGA中医证型分布与用药具有一定的地域规律，治疗应以“补益肝肾、健脾利湿”为基础治则，结合“南养阴血、北透血热”的地域策略，为中医地域化诊疗提供循证支持。

Abstract:

Abstract： Objective： To analyze the regional differences between northern and southern China in terms of traditional Chinese medicine syndrome types and medication patterns for androgenetic alopecia （AGA） based on data mining. Methods：Relevant literature on AGA was retrieved from the China National Knowledge Infrastructure（ CNKI）， Wanfang Data Knowledge Service Platform （Wanfang），China Science and Technology Journal Database （VIP），and China Biology Medicine disc（ CBM）. Clinical studies related to AGA were screened according to inclusion and exclusion criteria. Information on traditional Chinese medicine syndrome types， case numbers， prescriptions and medications， and geographic region distribution was extracted. Statistics of medication frequency， properties， flavors， meridian tropisms，and traditional Chinese medicine syndrome types were performed. Association rule and cluster analyses were conducted on high-frequency medications. Results： A total of 136 articles were included， involving 14 842 cases， 98 oral prescriptions， and 153 distinct Chinese medicines. The core traditional Chinese medicine syndrome types of AGA were predominantly damp-heat syndrome and liver-kidney deficiency syndrome. Blood deficiency syndrome was more common in southern China，while blood-heat syndrome was more prevalent in northern China. The most frequently used Chinese medicines included Glycyrrhizae Radix et Rhizoma，Poria，and Alismatis Rhizoma，among others. The medicinal properties were mainly cold， warm， and neutral； the flavors were predominantly sweet， bitter， and pungent；and the meridian tropisms were mainly the liver，spleen，and kidney meridians. Cluster analysis identified three core Chinese medicine combinations. Association rule analysis showed that the core Chinese medicine pairs in northern China included Atractylodis Macrocephalae Rhizoma-Chuanxiong Rhizoma and Atractylodis Macrocephalae Rhizoma-Polyporus，while those in southern China included Poria-Alismatis Rhizoma and Salviae Miltiorrhizae Radix et Rhizoma-Crataegi Fructus. Conclusion：Significant regional patterns exist in traditional Chinese medicine syndrome types and medication for AGA. The treatment should be based on the general principle of "tonifying the liver and kidney， strengthening the spleen and draining dampness，" while combined with regional strategies of "nourishing yin and blood in southern China" and "clearing blood heat in northern China， " thereby providing evidence-based support for the regionalized traditional Chinese medicine diagnosis and treatment.