基于数据挖掘分析中药复方治疗脓毒症相关性脑病用药规律

Analysis of Medication Rules of Chinese Medicine Compounds for Sepsis-Associated Encephalopathy Based on Data Mining

摘要:

目的：基于数据挖掘分析中药复方治疗脓毒症相关性脑病的用药规律。方法：检索中国知网、万方、超星、中国生物医学文献服务系统、Web of Science、PubMed数据库自建库至2025年11月发表的关于中医药治疗脓毒症相关性脑病的文献，利用Microsoft Excel 2021、SPSS Modeler18.0及SPSS Statistics 27对最终纳入的处方进行药物使用频次、药物性味归经统计及关联规则分析、聚类分析。结果：纳入处方29首，其中经方11首，自拟方18首，涉及中药73种。使用频次排前10位的药物分别为麝香、冰片、郁金、栀子、水牛角、大黄、黄连、黄芩、牛黄、朱砂等。药性以寒为主，温、平次之；药味以苦、辛为主；药物功效分类中使用频次排前5位分别为清热药、开窍药、活血化瘀药、平肝熄风药、补虚药；经关联规则分析，获得31组药物组合，其中麝香、冰片、郁金、栀子等药物存在强关联关系；因子分析将25味高频药物降维提取为7个不相关的公因子；聚类分析最终得出2类常用药物组合。结论：麝香和冰片为中药复方治疗脓毒症相关性脑病中使用最多的药物，治疗以清热解毒开窍为主，补虚贯穿全过程，同时注重活血化瘀，心、肝、肺、脾同治。

Abstract:

Abstract：Objective：To analyze the medication rules of Chinese medicine compounds in the treatment of sepsisassociated encephalopathy （SAE） based on data mining. Methods： Literature on TCM in the treatment of SAE published from each database's inception to November 2025 was retrieved from China National Knowledge Infrastructure （CNKI）， Wanfang Data Knowledge Service Platform （Wanfang）， Chaoxing， China Biomedical Literature Database （SinoMed）， Web of Science， and PubMed. Using Microsoft Excel 2021， SPSS Modeler 18.0， and SPSS Statistics 27，the finally included prescriptions were analyzed for frequency of herb use，properties，flavors， and meridian tropisms ，as well as association rule analysis and cluster analysis. Results：A total of 29 prescriptions were included，comprising 11 classical formulas and 18 self-formulated prescriptions，involving 73 Chinese herbs. The top 10 herbs in terms of frequency of herb use were Moschus，Borneolum Syntheticum，Curcumae Radix，Gardeniae Fructus，Bubali Cornu，Rhei Radix et Rhizoma，Coptidis Rhizoma，Scutellariae Radix，Bovis Calculus Artifactus， and Cinnabaris. In terms of medicinal properties， cold herbs were most common， followed by warm and neutral； in terms of flavors，bitter and pungent were predominant. By therapeutic effects，the top five were heat-clearing herbs， resuscitation-inducing herbs，blood-activating and stasis-resolving herbs，liver-calming and wind-suppressing herbs， and deficiency-tonifying herbs. Association rule analysis yielded 31 herbal combinations， with strong associations among Moschus，Borneolum Syntheticum，Curcumae Radix，Gardeniae Fructus，and others. Factor analysis reduced 25 high-frequency herbs to seven uncorrelated common factors. Cluster analysis identified two main categories of herbal combinations. Conclusion： Moschus and Borneolum Syntheticum are the most frequently used herbs in Chinese medicine compounds treatment of SAE. The therapy primarily focuses on clearing heat， removing toxicity， and inducing resuscitation， with deficiency-tonifying applied throughout the course， while also emphasizing blood activation and stasis resolution，and simultaneous treatment of the heart，liver，lung，and spleen.