Abstract: This paper introduces Professor YANG Peiqun's clinical experience in treating sequelae of ischemic stroke. Professor YANG posits that the core pathogenesis of this condition is deficiency in root and excess in manifestation, deficiency of kidney essence and depletion of the marrow sea, as well as deficiency of qi and blood, constitute the fundamental basis of the disease, while blood stasis obstructing the collaterals and phlegm turbidity clouding the orifices serve as the pathological manifestations. In terms of treatment, he advocates "taking classical formulas as the structural foundation and flexible prescriptions as the functional application, " emphasizing the simultaneous administration of cold and warm medicinals as well as simultaneous application of purging and nourishing therapeutics. He is particularly adept at employing insect-based medicinals to expel and remove pathogens within the collaterals. Furthermore, he innovatively applies the "Three Zhongjing Formulas" (Didang Decoction, Guizhi Fuling Pills,Guizhi Gegen Decoction) for the differentiation and treatment of carotid artery stenosis and plaque dissolution, thereby improving the pathological basis of sequelae of ischemic stroke and reducing the risk of recurrence.