葆宫止血颗粒联合激素替代疗法治疗肾虚肝郁型绝经综合征临床研究

Clinical Study of Baogong Zhixue Granules Combined with Hormone Replacement Therapy in Menopausal Syndrome of Kidney Deficiency and Liver Stagnation Type

摘要:

目的：观察葆宫止血颗粒联合传统激素替代疗法（HRT） 治疗绝经综合征的临床效果。方法：选取2023年8月—2025年8月诸暨市第六人民医院收治的100例绝经综合征患者，采用随机数字表法分为试验组与对照组各50例。试验组采用葆宫止血颗粒联合HRT治疗，对照组单纯给予HRT治疗。疗程均为3个月。比较2组临床疗效及不良反应发生率，以及治疗前后性激素水平［黄体生成素（LH）、雌二醇（E2）、卵泡刺激素（FSH）］、血清炎症因子［肿瘤坏死因子（TNF-α）、白细胞介素-6（IL-6）、白细胞介素-1β（IL-1β）］ 水平、子宫内膜厚度、绝经相关生活质量量表（MENQOL） 评分。结果： 治疗后， 试验组总有效率为94.00%（47/50），对照组为80.00%（40/50），2组比较，差异有统计学意义（P＜0.05）。治疗后，2组E2水平均较治疗前升高（P＜0.05），LH、FSH 水平均较治疗前降低（P＜0.05）；且试验组E2 水平高于对照组（P＜0.05），LH、FSH水平低于对照组（P＜0.05）。治疗后，2组TNF-α、IL-6、IL-1β水平均较治疗前降低（P＜0.05），且试验组3项指标水平均低于对照组（P＜0.05）。治疗后，2组子宫内膜厚度均较治疗前降低（P＜0.05），且试验组子宫内膜厚度薄于对照组（P＜0.05）。治疗后，2 组MENQOL 评分均较治疗前降低（P＜0.05），且试验组MENQOL评分低于对照组（P＜0.05）。治疗期间，试验组不良反应发生率为12.00%（6/50），对照组为18.00%（9/50），2组比较，差异无统计学意义（P＞0.05）。结论：葆宫止血颗粒联合HRT通过多靶点协同作用，在改善绝经综合征症状、调节内分泌功能及提升生活质量方面具有一定优势，且安全性良好。

Abstract:

Abstract： Objective： To observe the clinical efficacy of Baogong Zhixue Granules combined with conventional hormone replacement therapy （HRT） in patients with menopausal syndrome. Methods： A total of 100 menopausal syndrome patients admitted to Zhuji Sixth People's Hospital from August 2023 to August 2025 were selected and randomly divided into a trial group and a control group using the random number table method，with 50 cases in each group. The trial group received Baogong Zhixue Granules combined with HRT，while the control group received HRT alone. The treatment duration for both groups was three months. Clinical efficacy， incidence of adverse reactions， as well as levels of sex hormone [luteinizing hormone（ LH），estradiol（ E2），follicle-stimulating hormone（ FSH）]，serum inflammatory factor [tumor necrosis factor-alpha （TNF- α）， interleukin-6 （IL-6）， interleukin-1β （IL-1β）]， endometrial thickness， and Menopause-Specific Quality of Life （MENQOL） scores before and after treatment were compared. Results： After treatment， the total effective rate was 94.00% （47/50） in the trial group， significantly higher than that of 80.00% （40/50）in the control group （P＜0.05）. E2 levels increased in both groups after treatment （P＜0.05）， while LH and FSH levels decreased （P＜0.05）. The trial group showed higher E2 levels and lower LH and FSH levels than the control group （P＜0.05）. TNF-α，IL-6，and IL-1β levels decreased in both groups after treatment （P＜0.05）， with lower levels in the trial group （P＜0.05）. Endometrial thickness decreased in both groups （P＜0.05）， with thinner endometrium in the trial group （P＜0.05）. MENQOL scores decreased in both groups （P＜0.05）， with lower scores in the trial group （P＜0.05）. The incidence of adverse reactions was 12.00% （6/50） in the trial group and 18.00% （9/50） in the control group，with no significant difference between the two groups （P＞0.05）. Conclusion：Baogong Zhixue Granules combined with HRT，through multi-target synergistic effects，show advantages in alleviating menopausal syndrome symptoms，regulating endocrine function，and improving quality of life，with good safety.