黄莪胶囊联合泌淋颗粒治疗湿热瘀滞型慢性前列腺炎临床研究

Clinical Study on Huang'e Capsules Combined with Milin Granules for Chronic Prostatitis of Damp-Heat and Stasis Type

摘要:

目的：观察黄莪胶囊联合泌淋颗粒治疗湿热瘀滞型慢性前列腺炎的临床疗效。方法：回顾性选取2022年12月—2024年12月于台州市中心医院治疗的108例湿热瘀滞型慢性前列腺炎患者作为研究对象，根据治疗方案不同将患者分为对照组和观察组各54例。对照组给予黄莪胶囊口服，观察组在对照组基础上联合服用泌淋颗粒，连续服用6周。评价2组临床疗效，比较2组治疗前后慢性前列腺炎症状（NIH-CPSI） 评分、中医证候评分、尿动力学指标和炎症指标，统计不良反应发生率。结果：观察组总有效率为88.89%（48/54），高于对照组72.22%（39/54）（P＜0.05）。治疗后，2组各项中医证候评分较治疗前降低（P＜0.05），且观察组各项中医证候评分低于对照组（P＜0.05）。治疗后，2组最大尿流速、平均尿流速以及最大逼尿肌压力较治疗前升高，排尿前等待时间较治疗前缩短（P＜0.05）；且观察组最大尿流速、平均尿流速以及最大逼尿肌压力高于对照组，排尿前等待时间短于对照组（P＜0.05）。治疗后，2组NIH-CPSI评分、白细胞计数（WBC）、白细胞介素（IL） -8、IL-10水平较治疗前下降（P＜0.05）；且观察组NIH-CPSI评分、WBC、IL-8、IL-10水平低于对照组（P＜0.05）。2组不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：黄莪胶囊联合泌淋颗粒治疗湿热瘀滞型慢性前列腺炎能提升临床疗效，改善相关临床症状与尿动力学参数，减轻炎症反应，且用药安全性较好。

Abstract:

Abstract： Objective： To observe the clinical effect of Huang'e Capsules combined with Milin Granules in the treatment of chronic prostatitis of damp-heat and stasis type. Methods：A total of 108 patients with chronic prostatitis of damp-heat and stasis type treated at Taizhou Central Hospital from December 2022 to December 2024 were retrospectively selected and divided into the control group and the observation group according to different treatment regimens，with 54 cases in each group. The control group received oral Huang'e Capsules，while the observation group received additional Milin Granules on the basis of the control group. Both groups were treated continuously for six weeks. Clinical effects were evaluated. The scores of National Institutes of Health Chronic Prostatitis Symptom Index （NIHCPSI）， traditional Chinese medicine （TCM） syndrome scores， urodynamic parameters， and inflammatory markers were compared between the two groups before and after treatment，and the incidence of adverse reactions was recorded. Results：The total effective rate in the observation group was 88.89%（ 48/54），which was higher than 72.22%（ 39/54） in the control group （P＜0.05）. After treatment， the TCM syndrome scores in both groups were decreased when compared with those before treatment （P＜0.05），and the scores in the observation group were lower than those in the control group （P＜0.05）. After treatment， the maximum urinary flow rate， average urinary flow rate， and maximum detrusor pressure were increased， and the pre-voiding waiting time was shortened in both groups compared with that before treatment （P＜0.05）； and the maximum urinary flow rate， average urinary flow rate， and maximum detrusor pressure in the observation group were higher than those in the control group，while the pre-voiding waiting time was shorter than that in the control group （P＜0.05）. After treatment， the NIH-CPSI scores， white blood cell （WBC） count，and levels of interleukin-8 （IL-8） and interleukin-10 （IL-10） were decreased in both groups when compared with those before treatment （P＜0.05）； and the NIH-CPSI scores， WBC count， and IL-8 and IL-10 levels in the observation group were lower than those in the control group （P＜0.05）. There was no statistically significant difference in the incidence of adverse reactions between the two groups （P＞0.05）. Conclusion： Huang'e Capsules combined with Milin Granules can improve the clinical effect，ameliorate related clinical symptoms and urodynamic parameters， reduce inflammatory response，and the therapy exhibits good safety in the treatment of chronic prostatitis of damp-heat and stasis type.