从骨髓间充质干细胞成骨-成脂分化视角探讨补肾化浊法治疗激素性股骨头坏死

Exploration on Treatment of Bushen Huazhuo Therapy for Steroid-Induced Osteone⁃ crosis of the Femoral Head from the Perspective of Osteogenic-Adipogenic Differentia⁃ tion of Bone Marrow Mesenchymal Stem Cells

摘要:

激素性股骨头坏死（SONFH） 是非创伤性股骨头坏死中最常见的类型，其发病机制复杂，骨髓间 充质干细胞（BMSCs） 成骨与成脂分化失衡被认为是核心发病环节。在中医理论中，SONFH归属于骨蚀范畴， 以肾精亏虚为根本病因，浊邪痹阻为疾病进展的关键病机。针对这一病因病机特点，本文提出补肾化浊法为 SONFH的重要治法，该法强调以化浊为先、补肾为本的治疗特色，从BMSCs分化失衡的视角出发，系统探讨 补肾化浊法治疗SONFH的理论依据与临床实践路径，以期为该病的治疗提供中西医结合的新策略。

Abstract:

Abstract：Steroid-induced osteonecrosis of the femoral head （SONFH） is the most common type of non-traumatic osteonecrosis of the femoral head， with a complex pathogenesis. The imbalance between osteogenic and adipogenic differentiation of bone marrow mesenchymal stem cells （BMSCs） is considered a core pathological link. In traditional Chinese medicine （TCM） theory，SONFH falls under the category of bone erosion，with kidney essence deficiency as the fundamental etiology and obstruction by turbid pathogens as the key mechanism of disease progression. Based on these etiological and pathological characteristics， this article proposes Bushen Huazhuo （tonifying the kidney and resolving turbidity） therapy as a crucial treatment for SONFH. This approach emphasizes resolving turbidity as the priority and tonifying the kidney as the foundation. From the perspective of BMSCs differentiation imbalance，this article systematically explores the theoretical basis and clinical practice of Bushen Huazhuo therapy for SONFH， aiming to provide a new integrated strategy combining TCM and western medical perspectives for the treatment of SONFH.