Abstract:This article introduces PENG Xuming's clinical experience in treating migraine based on the theory of untying knot. PENG Xuming believes that the core pathogenesis of migraine lies in "pathogenic qi accumulating and knotting, obstructing the clear orifices." Guided by the theory of untying knot from Huang Di Nei Jing (The Yellow Emperor's Inner Classic),he categorizes "knots" into two levels:"knot in the collaterals" and "knot in the sinews." The "knot in the collaterals" pertains to the movement of qi and blood. By palpating the arteries of the head and face to differentiate deficiency and excess (categorized as excess knots or hidden knots),treatment involves either collateralpricking and bloodletting or reinforce and reduce with filiform needles accordingly. The "knot in the sinews" relates to the physical structure. Diagnosis involves tracing the sinews proximally and distally,and release is achieved using tuina and the lateral needling technique. By integrating the diagnostic and therapeutic approach of "untying knots by layer" with acupuncture and tuina,and unifying holistic and local treatment,satisfactory clinical effect can be achieved.