督灸联合微波治疗对结核性胸膜炎患者炎症因子及免疫功能的影响

Effects of Du Moxibustion Combined with Microwave on Inflammatory Factors and Immune Function in Patients with Tuberculous Pleurisy

摘要:

目的：观察督灸联合微波治疗对结核性胸膜炎（TP） 患者γ-干扰素诱导蛋白10（IP-10）、干扰素-γ（IFN-γ）、白细胞介素-17（IL-17）、肿瘤坏死因子-α（TNF-α） 及免疫球蛋白（Ig） M、IgG、IgA的影响。方法：选取2023年8月—2024年7月山东省公共卫生临床中心结核内四科收治的100例TP患者，按随机数字表法分为西医组及联合组各50例。西医组使用四联抗结核药物治疗，联合组在四联抗结核药物基础上增加督灸及微波治疗，比较2组治疗前后IP-10、IFN-γ、IL-17、TNF-α、IgM、IgG、IgA水平及临床症状评分的变化。结果：治疗后，2 组IP-10、IFN-γ、IL-17、TNF-α 水平均较治疗前下降（P＜0.05），联合组IP-10、IFN-γ、IL-17、TNF-α水平均低于西医组（P＜0.05）。治疗后，2组IgM、IgG、IgA水平均较治疗前升高（P＜0.05），联合组IgM、IgG、IgA水平均高于西医组（P＜0.05）。治疗后，2组乏力、畏寒、胸闷、气短临床症状评分均较治疗前下降（P＜0.05），联合组上述4项临床症状评分均低于西医组（P＜0.05）。结论：督灸联合微波治疗可有效抑制TP患者炎症反应，提升免疫力，缓解临床症状。

Abstract:

Abstract：Objective：To observe the effects of du moxibustion combined with microwave on interferon γ-induced protein 10 （IP-10）， interferon-γ （IFN-γ）， interleukin-17 （IL-17）， tumor necrosis factor-α （TNF-α）， and immunoglobulins IgM，IgG，and IgA in patients with tuberculous pleurisy （TP）. Methods：A total of 100 TP patients admitted to the Fourth Department of Tuberculosis at Shandong Public Health Clinical Center from August 2023 to July 2024 were selected and randomly divided into a western medicine group and a combination group using the random number table method，with 50 cases in each group. The western medicine group received quadruple anti-tuberculosis drug therapy， while the combination group received additional du moxibustion and microwave therapy on top of quadruple anti-tuberculosis drug therapy. Changes in IP-10，IFN-γ，IL-17，TNF-α，IgM，IgG，and IgA levels， as well as clinical symptom scores，were compared between the two groups before and after treatment. Results：After treatment，IP-10，IFN-γ，IL-17，and TNF-α levels decreased in both groups compared to before treatment （P＜ 0.05），with lower levels in the combination group than in the western medicine group （P＜0.05）. After treatment，IgM， IgG， and IgA levels increased in both groups compared to before treatment （P＜0.05）， with higher levels in the combination group than in the western medicine group （P＜0.05）. After treatment，clinical symptom scores for fatigue， aversion to cold，chest tightness，and shortness of breath decreased in both groups compared to before treatment （P＜ 0.05）， with lower scores in the combination group than in the western medicine group （P＜0.05）. Conclusion： Du moxibustion combined with microwave effectively suppresses inflammatory responses， enhances immunity， and alleviates clinical symptoms in patients with TP.